Agents against disorders of the frontal, paranasal and maxillary sinuses contain as active substance and extract of the fruits of squirting cucumbers (Ecballium elatrium). 29, No. However, it was associated with undesirable effects such as the irritation of nasal mucous membranes, uvular angioedema, drooling, dysphagia and vomiting (Raikhlin-Eisenkraft and Bentur, 2000). [Uvular edema. Only one brand/specific product has been selected. Effect of ethanolic extract of Ecballium elaterium against Staphylococcus aureus and Candida albicans. Elaterium is the cucurbitacin extract used in ancient history as a purgative in folk medicine. Pure and extract forms of E elaterium were applied to the nasal cavity of rats for the treatment of Streptococcus-pneumoniae -induced rhinosinusitis. SKU: N/A Categories: Cucumbers & Relatives, Herbs & Spice, Seeds, Vegetables & Spices. Ecballium elaterium part extracts tested showed various degrees of inhibition against the 6 bacterial strains tested using the microdilution method as presented in table2. Would you like email updates of new search results? In this letter, the authors present evidences suggesting that the intranasal use of the fruit juice of Ecballium elaterium (diluted form, 1 drop in each nostril) is effective and safe in patients with acute rhinosinusitis and negative history of allergies. Study Start Date : November 2007: Actual Primary Completion Date : January 2009: Actual Study Completion Date : February 2010: Resource … : Spritzgurke. Otolaryngologists are frequently asked to diagnose and treat such an emergency situation. Rare complication in anesthesia]. Chem. Extract of Ecballium elaterium has been known as an anti-inflammatory agent in the Mediterranean region for many centuries and it has been used as a remedy against a vast spectrum of diseases, mainly against chronic and acute sinusitis. Privacy, Help Botanical name: Ecballium elaterium. Problems: Sinusitis. Ecballium elaterium (squirting cucumber) contains toxic cucurbitacins, which are violent purgatives. 2014 Jul;63(7):574-7. doi: 10.1007/s00101-014-2341-8. Study Start Date : November 2007: Extract of Ecballium elaterium has been known as an anti-inflammatory agent in the Mediterranean region for many centuries and it has been used as a remedy against a vast spectrum of diseases, mainly against chronic and acute sinusitis. Ecballium elaterium is a plant that grows in the Mediterranean countries. Intratympanic dexamethasone for sudden sensorineural hearing loss after failure of systemic therapy. US$ 49.95. Helps expel mucus from the paranasal sinuses. Laryngoscope. In 3 other cases, children ingested the fruit unwittingly. In 3 patients, exposure was intranasal for the treatment of sinusitis or liver cirrhosis. 2011 Dec;1(6):456-60. doi: 10.1016/S2221-1691(11)60100-7. FDA is not aware of scientific evidence to support homeopathy as effective. Practical Herb Cards 2 is here. However, adverse reactions in some patients with a positive history of allergy should always be considered. It is used in the Mediterranean as a purgative and in treating sinusitis. It is often Ecballium elaterium were collected from green mountain used in dropsy (edema), especially pulmonary edema and area in Benghazi, Libya during November 2013. also as a revulsive in brain diseases [4]. ABSTRACT Purpose: this study aims to approve the folk uses for Ecballium elaterium [(L.) A. Epub 2012 Jan 19. Epub 2014 Jul 12. 2017 May 8;13(1):27. doi: 10.1186/s13002-017-0151-1. Engl. The flowering, the fruiting and the harvesting take place from June to August. Objectives: The effects of this particular extract are known empirically through time. 1). Study design: Folk remedies still in use: a case of soft palate and uvular oedema due to Ecbalium elaterium. Skin prick and prick-to-prick testing to various allergens was performed in 12 patients. Human Exposure to Ecballium elaterium Fruit Juice: Fatal Toxicity and Possible Remedy. Fig. The subject will complete the study at the first control visit without symptoms. Diagnosis of acute episode of sinusitis (in an acute, subacute or chronic background), confirmed with a CT scan image. It is frost tender. Price includes VAT for USA. Usually the fruit of the Ecballium elaterium is used to treat sinusitis because of its anti-inflammatory properties [1]. Read our, ClinicalTrials.gov Identifier: NCT00747747, Interventional D. S. Deenadayal, B. Naveen Kumar, K. Lakshmi Sameeri Crude aqueous infusion were prepared by adding 100 ml of boiling water on 25 g of powdered plant materials in a glass 250-ml flask and incubated at room temperature on a rotating shaker (200 rpm) for 20 min. U.S. Department of Health and Human Services, The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Opiskele yrttiterapiaa etänä! The squirting cucumber plant is widely used in the treatment of sinusitis, rheumatism, and hepatitis.It is reported that the liquid obtained from fruits is widely used in the treatment of sinusitis among people, especially in Turkey.  (Clinical Trial). Many people in this region for the treatment of sinusitis use the juice of its fruit. However, allergy-prone patients after using it may sometimes present with edema at various sites of the upper respiratory tract. Deu. To present a rare occurrence in ear, nose and throat practice of upper airway allergic edema from use of juice extracted from the fruit of Ecballium elaterium. We think a further study of the pharmaceutical properties of the plant's fruit juice is needed, especially regarding its curative properties of rhinitis and sinusitis. The patient is requested to evaluate his state of symptoms by recording in a diary. Keywords: Ecballium elaterium; Cucurbitacine; Uvular Edema; Sinusitis; Rhinitis, Conjunctivitis; Angioedema; Soft Palate; Hypoxemia. The human serious adverse reactions of the folkloric plant, Ecballium elaterium (EE), are well documented in the literature. Pediatric sinusitis is a common problem treated by primary care physicians and otolaryngologists. An in vitro study on the risk of non-allergic type-I like hypersensitivity to Momordica charantia. This report is presenting the medical literature of 74 cases, which experienced severe adverse reactions or deaths that resulted from the administration of the plant juice. Rich. Intranasal use of E. elaterium has been associated with angioedema [4] and with fatal cardiac and renal failure [5]. Th … Ecballium for sinusitis. Skin tests elicited positive reactions to pollen weeds and to various fruits of the Cucurbitaceae family. However, the authors also state that further controlled studies are needed to prove the benefits of this therapy. Choosing to participate in a study is an important personal decision. Many people in this region for the treatment of sinusitis use the juice of its fruit. FDA is not aware of scientific evidence to support homeopathy as effective. Objectives To present a rare occurrence in ear, nose and throat practice of upper airway allergic edema from use of juice extracted from the fruit of Ecballium elaterium .. Introduction Ecballium elaterium is a plant indigenous to the Mediterranean region that bears the common name squirting cucumber. Ecballium elaterium is most often described as a Mediterranean plant but it can survive harsh environmental conditions. 18 Years and older   (Adult, Older Adult), University Cattolica del Sacro Cuore Roma Italy. It is in flower from Jun to August, and the seeds ripen from Aug to September. Haynes DS, O'Malley M, Cohen S, Watford K, Labadie RF. @article{Sezik1995ClinicalEO, title={Clinical effects of the fruit juice of Ecbalium elaterium in the treatment of sinusitis. Introduction: Ecballium elaterium is a plant indigenous to the Mediterranean region that bears the common name squirting cucumber. Clipboard, Search History, and several other advanced features are temporarily unavailable. Patient's daily diary retrospective ranked assessment of symptoms (0,1,2,3 with 0 = no symptoms; frequencies of patients with rank "0" were compared as outcome measure between groups. Accessibility Unable to load your collection due to an error, Unable to load your delegates due to an error. Add to cart. Why Should I Register and Submit Results? Children with occasional episodes of acute sinusitis following a routine cold are treated with … Disclaimer: This homeopathic product has not been evaluated by the Food and Drug Administration for safety or efficacy. It prefers dry or moist soil and follows the Med - Irano-Turanian Chorotype. Head Neck Surg. Divlji krastavac (lat.Ecballium Elaterium) je dugogodisnja, dlakava, mediteranska biljka s prizemnom stabljikom iz porodice tikvi (lat.Cucurbitaceae). Practical Herb Cards 2. You have reached the maximum number of saved studies (100). Metrics details. This report is presenting the medical literature of 74 cases, which experienced severe adverse reactions or deaths that resulted from the administration of the plant juice. Plod je dlakava i bradavicasta duguljasta bobica. Biljka je poznata od davnina kao jako djelotvorno sredstvo u borbi protiv alergija i problema sa sinusima. Fractions obtained from the juice were tested in mice for their effects on increased vascular permeability, as induced by HOAc ip. -----Ecballium Elaterium extract PURPOSE Helps expel mucus from the paranasal sinuses. It belongs to the Cucurbitaceae family. methanol or ethanol. ... Read more about Ecballium for sinusitis. Saline solution sprayed according to the product indication. Ecballium elaterium. The fruit juice of Ecballium elaterium, used as a folk medicine in Turkey for the treatment of sinusitis, was investigated for its anti-inflammatory activity in mice. … Many people in this region for … The flowering, the fruiting and the harvesting take place from June to August. The fruit juice of Ecballium elaterium, used as a folk medicine in Turkey for the treatment of sinusitis, was investigated for its anti-inflammatory activity in mice. : squirting cucumber, jumping cucumber, wild balsam-apple, wild cucumber. Disclaimer: This homeopathic product has not been evaluated by the Food and Drug Administration for safety or efficacy. Investigation of cytotoxic and genotoxic effects of Ecballium elaterium juice based on Allium test. Yes, folklorically Ecaballium elaterium friut juice (it has a juice in the fruit, and squirting action is due to this juice) is used for sinusitis by a single drop into your nose... My M.D. Description Additional information Reviews (0) Description Squirting Cucumber. The present invention concerns a pharmaceutical composition comprising Ecballium Elaterium juice and uses thereof in medical field for the treatment of the infectious and allergic rhinitis, rhino-sinusitis … 2007 Jan;117(1):3-15. doi: 10.1097/01.mlg.0000245058.11866.15. Helps expel mucus from the paranasal sinuses. Date: Tue, 11 Jun 1996 11:13:35 UTC Sender: HERB.TREARNPC.EGE.EDU.TR From: suleyman Subject: something for sinusitis. Therapeutic potential of E. elaterium as an anti-inflammatory agent was examined by measurement of NO* metabolites in a rabbit model of rhinosinusitis. Please remove one or more studies before adding more. It is used in the Mediterranean as a purgative and in treating sinusitis. Ecballium elaterium Ecballium elaterium 2013-01-12 00:00:00 Reactions 1396 - 7 Apr 2012 Uvular oedema and hypoxaemia: case report A 52-year-old man developed severe uvular oedema and subsequent hypoxaemia following a single administration of Ecballium elaterium. Alcohol abuse or other dependencies on stupefacents, History of intolerance or allergy to the components of SINUclean DM®, Surgical or medical intervention that can jeopardize the complete performance of the trial, in the 4 wks preceding the administration of the informed consent, Planning of a surgical or medical intervention that can jeopardize the completion of the trial. Abdulazim S. Salhab. Ecballium elaterium (L.) also known as “wild or squirting cucumber” is a plant from the cucumber family (Cucurbitaceae), ... (Toker et al., 2003), sinusitis and painful joints by nasal aspiration. The agents are highly active in cleaning various secretions from the sinuses and in the treatment of sinusitis, for which purpose they are administered in the form of nasal drops (pref. Extracted from the juice of the fruit of E. elaterium, elaterium was discovered by Stirling in 1835. The first attempt to prove Agents against disorders of the frontal, paranasal and maxillary sinuses contain as active substance and extract of the fruits of squirting cucumbers (Ecballium elatrium). Vol.4 No.5, August 20, 2013 DOI: 10.4236/pp.2013.45064 HTML Chronic Sinusitis with Frontal Mucocele: A Case Report D. S. Deenadayal, B. Naveen Kumar, K. Lakshmi Sameeri Int. If possible it will be assessed the status of paranasal sinuses before and after the treatment with a CT scan. It has the formula C 32 H 44 O 7. Helps reduce symptoms of sinusitis (headache, facial pain, heavy head, nasal obstruction, malaise). 2009 Nov;31(9):591-6. doi: 10.1358/mf.2009.31.9.1434629. Effects of Ecballium Elaterium on Proinflammatory Cytokines in a Rat Model of Sepsis 18 May 2016 | Journal of Investigative Surgery, Vol. An ethnopharmacological evaluation of Navapind and Shahpur Virkanin district Sheikupura, Pakistan for their herbal medicines. Participation to other clinical trials, ongoing or terminated since less than 30 days before the beginning of the present experiment. The fruits are oval, approximately 3cm, covered with short hair. Keywords: Ecballium elaterium; Cucurbitacine; Uvular Edema; Sinusitis; Rhinitis, Conjunctivitis; Angioedema; Soft Palate; Hypoxemia . We have observed that the type of solvent used to extract the different parts of Ecballium elaterium can have a great impact on the antimicrobial activity. Eng. Ecballium elaterium. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. Anti-histaminic, steroidal anti-inflammatory drugs are forbidden. Engl. Although this disorder has been addressed for many centuries, full appreciation for its scope, pathophysiology, diagnosis, treatment, and complications has been realized only relatively recently. SINUS ERUNT su kapi bez ikakvih hemijskih dodataka i pokazale su se efektivnim u liječenju maloprije pomenutih simptoma. Ecballium elaterium, the squirting cucumber, from the Cucurbitaceae family, has been known in the Mediterranean area as a medicinal plant since antiquity. 6 Human Exposure to Ecballium elaterium Fruit Juice: Fatal Toxicity and Possible Remedy FDA is not aware of scientific evidence to support homeopathy as effective. Helps expel mucus from the paranasal sinuses. Possible necessity of treatment, during the study, with drugs that are not allowed (see section "Concomitant Therapy"). The treatment intervals is the week. USES. The juice of the fruit of Ecballium elaterium has been known as an anti-inflammatory, cathartic, analgesic agent and it has been used for treatment constipation, pulmonary edema, ascites and especially sinusitis in the Safety and Efficacy (for Symptoms Remission) of the Treatment of the Acute Episode of Sinusitis With Ecballium Elaterium (SINUclean DM® Nasal Spray) as Co-adjuvant of the Antibiotic Therapy: Comparative, Prospective, Randomized, Open Study. Air dried fruits of squirting cucumbers (Ecballium elaterium) were purchased from retail shops in Erzurum, Turkey, and then ground into a powdered material by using a coffee mill. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00747747. This site needs JavaScript to work properly. Human Exposure to Ecballium elaterium Fruit Juice: Fatal Toxicity and Possible Remedy Abdulazim S. Salhab Pharmacol. Rich.] The fruits are oval, approximately 3cm, covered with short hair. This difference could The plant is a very powerful purgative that causes evacuation of water from the bowels. ABSTRACT. Methods Find Exp Clin Pharmacol. Etäopiskelu. DOI: 10.3109/15563659509028931 Corpus ID: 34355370. The plant EE, known as squirting cucumber, is a weed belongs to cucurbitacea family. Ecballium elaterium is a plant indigenous to the Mediterranean region that bears the common name squirting cucumber. Helps reduce symptoms of sinusitis (headache, facial pain, heavy head, nasal obstruction, malaise). Instant access to the full article PDF. Ecballium elaterium is a plant that grows in the Mediterranean countries. For general information, Learn About Clinical Studies. The squirting cucumber has been used as a medicinal plant for over 2,000 years, though it has a very violent effect upon the body and has little use in modern herbalism. We search about phytochemicals, which improve Ecbalium elaterium (Picture 1), belongs to Cucurbitaceae family, takes place in alternative medicine because of cytotoxic, analgesic and purgative effects of the bioactive … Extracts of the fruit are still used in different folk medicinal systems in the Mediterranean region, especially as a curative agent against sinusitis, inflammation, rheumatism, liver disorders and jaundice. Zahoor M, Yousaf Z, Aqsa T, Haroon M, Saleh N, Aftab A, Javed S, Qadeer M, Ramazan H. J Ethnobiol Ethnomed. Examination revealed severe uvular oedema and a low oxygen saturation. This report is presenting the medical literature of 74 cases, which experienced severe adverse reactions or deaths that resulted from the administration of the plant juice. Bethesda, MD 20894, Copyright The fruit juice of E. elaterium has been used in the Anatolia region for inflammatory diseases like rhinosinusitis because of its potent cathartic, analgesic, and anti-inflammatory effects 1. Patient records were retrospectively reviewed for age, sex, presenting symptoms, physical examination, and medical treatment. Pharm. Ecballium elaterium is a perennial, self-sown, herbaceous plant growing up to 1m, with thick, green, heart-shaped or triangular leaves and small, yellow flowers. SINUCLEAN — ecballium elaterium fruit spray Galsor S.r.l. Symptoms of facial pain associated to the congestion of the mucosa of the paranasal sinuses for at least three days. Ecballium elaterium (L.) A. Clinical assessment of healing of the sinusitis episode (Outcome Measure Percentage of patients healed. Treatment of the patients with corticosteroids and antihistamines resulted in an uneventful recovery, and we did not need to resort to therapeutic modalities, such as intubation or tracheotomy. It is used internally in the treatment of edema associated with kidney complaints, heart problems, rheumatism, paralysis, and shingles. Healing was assessed clinically by the physician as recovery of the condition prior to the diagnosis of the episode of sinusitis, without need of medical treatment. Most of the patients presented with localized swelling of the uvula and the nasal mucosa, whereas in the remainder of the patients various sites of swelling of the upper respiratory tract were observed. Jul 4, 2014 - Find many great new & used options and get the best deals for Squirting Cucumber/Ecballium elaterium Tincture, 20 ml, Sinusitis at the best online prices at eBay! Presence of Mucus in the Paranasal Sinuses (Outcome Measure Percentage of Patients) [ Time Frame: After one week ], Presence of Mucus in the Paranasal Sinuses (Outcome Measure Percentage of Patients) [ Time Frame: After two weeks ], FACIAL PAIN Daily Retrospective Ranking of Symptoms as Assessed by the Subject [ Time Frame: After one week ], FACIAL PAIN Daily Retrospective Ranking of Symptoms as Assessed by the Subject [ Time Frame: After two weeks ], Recovery of Sinusitis Per Clinical Assessment(Outcome Measure Percentage of Patients) [ Time Frame: After one week ], Recovery of Sinusitis Per Clinical Assessment (Outcome Measure Percentage of Patients) [ Time Frame: After two weeks ]. 2007;26 Suppl 1:3-106. doi: 10.1080/10915810601163939. Helps expel mucus from the paranasal sinuses. Safety and Efficacy (for Symptoms Remission) of the Treatment of the Acute Episode of Sinusitis With Ecballium Elaterium (SINUclean DM® Nasal Spray) as Co-adjuvant of the Antibiotic Therapy: Comparative, Prospective, Randomized, Open Study. FOIA Koussidis GA, Mountantonakis S, Petrichou CC. Ecballium elaterium is a perennial plant, growing to 0.3 m (1ft) by 1 m (3ft 3in). The Review. Clinical assessment of healing of the sinusitis episode(Outcome Measure Percentage of patients healed). However, it may cause allergic, toxic, and systemic adverse reactions in some users. SINUCLEAN - ecballium elaterium solution spray Galsor S.r.l Disclaimer: This homeopathic product has not been evaluated by the Food and Drug Administration for safety or efficacy. The agents are highly active in cleaning various secretions from the sinuses and in the treatment of sinusitis, for which purpose they are administered in the form of nasal drops (pref. Results: Anaesthesist. In case of female subject: ongoing pregnancy or lactating; or condition of fecundity without abstinence. for treatment of hemorrhoids, varicose veins also for nose bleeding in the West Bank-Palestine. Yes, folklorically Ecaballium elaterium friut juice (it has a juice in the fruit, and squirting action is due to this … Expressed intention of compliance with the study requirements. Extracts of the fruit are still used in different folk medicinal systems in the Mediterranean region, especially as a curative agent against sinusitis, inflammation, rheumatism, liver disorders and jaundice. Severe uvular edema and resulting hypoxemia due to single use of Ecballium elaterium extract. Healing was assessed clinically by the physician as recovery of the condition prior to the diagnosis of the episode of sinusitis, without need of medical treatment. Cveta od maja do septembra. Introduction: Rich fruit juice 173 Maced. Facilitates recovery sinusitis attack. He had administered undiluted Ecballium elaterium extract nose drops earlier that day for sinusitis [dose and time to reaction onset not stated]. The significance of this study depends on the facts that Ecballium elaterium is a mediterranean medicinal plant used as an analgesic and in treatment of hemorrhoids; fruits in sinusitis, jaundice, nocturia, lumbago and otalgia as well as other conditions thought to be inflammatory in nature including rheumatism and infections. 2008 Mar;46(3):257-8. doi: 10.1080/15563650601158834. Am J Case Rep. 2012;13:11-3. doi: 10.12659/AJCR.882292. Search the information of the editorial board members by name. Free delivery for many products! The human serious adverse reactions of the folkloric plant, Ecballium elaterium (EE), are well documented in the literature. The scientific work described in Part II of this two part article has been performed using water-distilled extracts of Ee which grows in the Middle East, notably the Sinai desert region, Northern or Southern Egypt, Jordan and Libya. After baseline and start of treatment, are planned two control visit. Severe uvular edema and nasal mucosal necrosis due to Ecbalium elaterium (squirting cucumber): an allergic reaction or direct toxic effect? The plant is perennial, fleshy, rough hairy with stems 30 - … Clin Toxicol (Phila). To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. DOI: 10.4236/pp.2013.45064 3,700 Downloads 6,293 Views Citations Chronic Sinusitis with Frontal Mucocele: A Case Report. No coadiuvant treatment. Uvular oedema and hypoxaemia: case report. Be component of the investigators' staff or be a relative of a member of the staff. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Pharmacology & Pharmacy Vol.4 No.5，August 20, 2013 . Order your set today! Retrospective review of the records of 42 patients with this condition during the last 4 years. In 6 patients, exposure was ocular and, in one, dermal. Many people in this region for the treatment of sinusitis use the juice of its fruit. Fractions obtained from the juice were tested in mice for their effects on increased vascular permeability, as induced by HOAc ip. The cucurbitacins are a group of highly oxygenated tetracyclic triter- penes having a unique 19-(10→9β)-abeo-10-lanost-5-ene (cucurbitane) skeleton (Fig. Seasonal distribution and data from the history of the patients were also considered. Clinical effects of the fruit juice of Ecbalium elaterium in the treatment of sinusitis. National Library of Medicine Ecballium elaterium is also known as squirting cucumber. In Turkey, many people use the juice or ground powder of squirting cucumber (Ecballium elaterium (L.) T. Richard, Cucurbitaceae) fruits for treatment of rhinosinusitis. This study aimed to evaluate the antimicrobial effects of the medicinal plant Ecballium elaterium, which is topically applied as a traditional medicine for the treatment of rhinosinusitis. 3 sprays per nostrils twice a day (morning and evening); in case of need a third nebulization between the two is allowed, Mucus detection in paranasal sinuses by clinical assessment(Outcome measure Percentage of patients), Mucus detection in paranasal sinuses by clinical assessment(Outcome Measure Percentage of patients), Patient's daily diary retrospective ranked assessment of symptoms (0,1,2,3 with 0 = no symptoms; frequencies of patients with rank "0" were compared as outcome measure between groups. Prevention and treatment information (HHS). After the second visit, if the symptoms are still present, the subject will complete as a "treatment-failure". friends usually ask me to get it, they use also... but since it is not proved scientifically, neither of our friends can advise it to the patients.. Introduction Ecballium elaterium is a plant indigenous to the Mediterranean region that bears the common name squirting cucumber. Click here for photos of Ecballium elaterium.. Ecballium elaterium (L.) A. Int J Toxicol. Ecballium elaterium, the squirting cucumber, from the Cucurbitaceae family, has been known in the Mediterranean area as a medicinal plant since antiquity. Cvet je svetlo zute boje, zvonastog oblika, jednopolan i nalazi se u pazuhu lista. USES Reduces intensity and duration of sinusitis symptoms. E. elaterium is weed plant indigenous to the Mediterranean Basin, and known as an officinal herb of a long tradition and large variety of uses in Turkey [4] , [5] . The active WARNING Access options Buy single article. 18 Accesses. Please enable it to take advantage of the complete set of features! Talk with your doctor and family members or friends about deciding to join a study. Externally, it has been used to treat sinusitis and painful joints. Ecballium Elaterium extract PURPOSE Helps expel mucus from the paranasal sinuses. Rent this article via DeepDyve. Ecballium elaterium has been widely used as a treatment for Hepatitis C (viral infection (HCV) in Egypt. Elaterin is extracted from elaterium by chloroform and then precipitated by ether. The human serious adverse reactions of the folkloric plant, Ecballium elaterium (EE), are well documented in the literature. Reduces intensity and duration of sinusitis symptoms. Also, cytotoxic effect of freeze-dried extract from E. elaterium fruits has been demonstrated on gastric adenocarcinoma (AGS) and esophageal 38 (2), 171–182 (2019) T a b l e 1 Analytical and preparative methods for the analysis of cucurbitacins by HPLC Stationary phase (Column) Mobile phase Flow rate (mL/min) Elution type and program Determined It also has well-known hydragogue cathartic, antitumor, antimicrobial, and anti-inflammatory effects8,9. This study aimed to evaluate the antimicrobial effects of the medicinal plant Ecballium elaterium, which is topically applied as a traditional medicine for the treatment of rhinosinusitis. Information provided by (Responsible Party): The goal of the study is to demonstrate that SINUclean DM® spray, added to the standard (amoxicillin/clavulanate) therapy of the acute episode of sinusitis (acute, subacute or chronic), is safe ad capable to determine the resolution of the symptoms in a shorter time in comparison with the standard therapy without co-adjuvant, or with simple saline lavage.